Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes

Peer reviewedPublisher PD

The effect of grape interventions on cognitive and mental performance in healthy participants and those with mild cognitive impairment : a systematic review of randomized controlled trials

Funding: We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS) and the University of Aberdeen for funding.Peer reviewedPublisher PD

A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle

Peer reviewedPublisher PD

Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations : A Systematic Review of the Literature

Funding: This research was funded by By-Health Co. Ltd., Guangzhou, China. G.H., N.H., W.R.,and B.d.R. are funded by the Scottish Government Rural and Environmental Science and Analytical Services (RESAS)Peer reviewedPublisher PD

The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transporters

We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS), the University of Aberdeen and Nutricia Research Foundation for funding. We thank Graham Horgan from Biomathematics and Statistics Scotland for their assistance with the statistical analysis. We thank Gordon J. McDougall and Rex M. Brennan, from The James Hutton Institute for supplying the currants. None of the authors had any conflicts of interest.Peer reviewedPostprin

A comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue

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Analysis of polyphenolic metabolites from in vitro gastrointestinal digested soft fruit extracts identify malvidin-3-glucoside as an inhibitor of PTP1B

Acknowledgements We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS), the University of Aberdeen and Nutricia Research Foundation for funding. We thank Graham Horgan from Biomathematics and Statistics Scotland for their assistance with the statistical analysis. We thank Gordon J. McDougall and Rex M. Brennan, from The James Hutton Institute for supplying the soft fruits.Peer reviewedPostprin

Can CANVAS due to RFC1 biallelic expansions present with pure ataxia?

BACKGROUND: Biallelic expansion of AAGGG in the replication factor complex subunit 1 (RFC1) was identified as a major cause of cerebellar ataxia, neuropathy (sensory ganglionopathy, or SG) and vestibular areflexia syndrome (CANVAS). We wanted to clarify if RFC1 expansions can present with pure ataxia and if such expansions could be responsible for some cases where an alternative diagnosis had been made. METHODS: We identified patients with a combination of ataxia and SG and no other cause found, patients where an alternative diagnosis had been made, and patients with pure ataxia. Testing for RFC1 expansions was done using established methodology. RESULTS: Among 54 patients with otherwise idiopathic sporadic ataxia without SG, none was found to have RFC1 expansions. Among 38 patients with cerebellar ataxia and SG in which all other causes were excluded, 71% had RFC1 expansions. Among 27 patients with cerebellar ataxia and SG diagnosed with coeliac disease or gluten sensitivity, 15% had RFC1 expansions. CONCLUSIONS: Isolated cerebellar ataxia without SG makes the diagnosis of CANVAS due to RFC1 expansions highly improbable, but CANVAS is frequently the cause of the combination of idiopathic cerebellar ataxia with SG. It is important to screen patients diagnosed with other causes of acquired ataxia and SG as a small percentage were found to have RFC1 expansions

A randomised, double-blind, cross-over trial to evaluate bread, in which gluten has been pre-digested by prolyl endoprotease treatment, in subjects self-reporting benefits of adopting a gluten-free or low-gluten diet

Acknowledgements We are grateful for the support of the staff from the Rowett Institute Human Nutrition Unit. The present study was supported by a grant (Bakery Products for Non-Coeliac Gluten sensitive Consumers) from Innovate UK (101740). The funder Innovate UK had no role in the design, analysis or writing of this article. Warburton Ltd. provided the experimental bread. DSM Food Specialities B.V. provided the protease ANPEP. The study is registered under the Clinical Trials Identifier: NCT02308397. NH proposed the study concept. NH and DR designed research. DR recruited the subjects and carried out the intervention, laboratory analysis, data collection and collation. MC and KM helped with recruitment. GC performed the analysis of the breads. GH and DR analysed the data. DR prepared the manuscript; NH had primary responsibility for final content. All authors read and approved the final manuscript. The authors have no financial or personal conflicts of interest to declare.Peer reviewedPublisher PD